Reducing the expression of the PHD2 oxygen sensor impairs the ability of breast cancers to metastasize (spread) to other parts of the body, scientists have discovered. Breast cancer is the second ...

B55α is one of the regulatory subunits of the PP2A phosphatase. This phosphatases has been associated to the control of many biological functions but the multiplicity of complexes that can be formed ...

The authors state that the PHD2 mutation affects the stability and functions of hypoxia-inducible factor (HIF) and that prolyl hydroxylase (PHD) inhibitors should be evaluated for an oncogenic effect.

Scientists have identified a new mechanism that impacts tumor growth. The typical lack of oxygen in tumors doesn't only stimulate proliferation, but also offsets the important role of the protein PHD2 ...