C&EN

Increasing Proteome Coverage Through a Reduction in Analyte Complexity in Single-Cell Equivalent Samples

Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States Proteome Exploration Laboratory, Beckman ...
The Lancet

The mediating role of neuroimaging-derived biological brain age in the association between risk factors for dementia and cognitive decline in middle-aged and older individuals ...

hDepartment of Veterans Affairs Medical Center, Northern California Institute for Research and Education, San Francisco, CA, USA iDepartment of Radiology, University of California, San Francisco, CA, ...
Europe PMC

Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2.

Engineered cytokine-based approaches for immunotherapy of cancer are poised to enter the clinic, with IL-12 being at the forefront. However, little is known about potential mechanisms of resistance to ...
Europe PMC

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.

We present an integrated analysis of the clinical measurements, immune cells, and plasma multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial blood draws ...
C&EN

Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Unfortunately, PTPs, including SHP2, have proven to be an ...